Health & wellbeing solutions – research outlines

Choose a research outline for your application

"Exercise is medicine" for neuromuscular diseases (RFO-25028)

Exercise has been termed a “miracle cure” by the Academy of Medical Royal Colleges, but the optimal type and dose of exercise for people with neuromuscular diseases is still debated. Our research program focuses on studying the pathophysiology of different neuromuscular diseases, and then using this knowledge to design tailored exercise programs to produce optimal improvements in aerobic fitness, strength, physical function, and quality of life. 

Thanks to the interdisciplinary expertise of our research group, we are able to combine many sophisticated methods in one study (brain imaging, high-density surface electromyography, proteomics) to provide the most complete description of how exercise affects the whole motor system (brain, spinal cord, muscle), and to define the best exercise options. To continue this research, we are looking for potential applicants with a background in exercise physiology and/or experience training people with different diseases.

Supervisors: Dr Alessandra Ferri, Professor David Bishop
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Dr Alessandra Ferri,  [email protected]   

Advancing communicative brain-computer interface technology using explainable AI for motor-disabled people (RFO-25029)

This project aims to advance communicative Brain-Computer Interface (BCI) technology by developing an explainable artificial intelligence (XAI)-based framework to identify communicative intentions in individuals with motor disabilities using real-time EEG data. Existing BCI systems lack adaptability and transparency, relying on black-box AI models that limit trust, interpretability, and clinical usability. To address these limitations, this research will integrate XAI with advanced data mining techniques to create a robust, real-time BCI framework capable of decoding brain signals for effective communication. A prototype system will be developed and validated to support assistive device innovation. 

The project will generate new knowledge in XAI-based BCI, enabling scalable processing of brain data into actionable insights. Expected outcomes include optimised XAI models and a functional prototype, contributing to improved quality of life for motor-disabled individuals and reducing healthcare burdens. The work supports innovation in neurotechnology, healthcare accessibility, and smart assistive systems in Australia and globally.

Supervisors: Dr Siuly Siuly, Professor Hua Wang
Institute: Institute for Sustainable Industries & Liveable Cities
Course Code: UPAF
Field of Research (FoR) Code: 4602 Artificial intelligence

To indicate your interest and discuss your suitability, please contact: Dr Siuly Siuly,  [email protected]   

Advancing research in tracking unmet health & social care needs of older populations (RFO-25030)

Population ageing presents a shift in health needs, leading to an increase in disease burden emanating from the onset of health conditions and disabilities. Many of these chronic diseases, their risks, and consequences are modifiable, and their outcomes can be improved by accessing quality health and social care services. However, in many countries, the health and social needs of older people are not being met for a portion of the population. These gaps resulting from the health and social care need to raise issues of equity in service coverage and healthcare universality. Interestingly, available measures of universal health coverage do not assess unmet needs, nor do they adequately capture services that older persons require, including social care. PhD students are welcome to use any research approach including, mixed-methods, quantitative, and qualitative approaches to study the topic. They can use either secondary datasets or primary data to investigate their chosen topic.

Supervisors: Associate Professor Bernadette Saunders, Dr Kofi Awuviry-Newton
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4206 Public Health

To indicate your interest and discuss your suitability, please contact: Associate Professor Bernadette Saunders,  [email protected]   

Aerosol transport & ventilation optimisation in ambulance environments: CFD and experimental investigations to enhance paramedic safety (RFO-25031)

This PhD project aims to investigate gas-particle flow behaviour and aerosol dispersion within the confined environment of an ambulance, with a particular focus on the rear patient compartment where paramedics deliver critical care.

A key area of interest is the use of inhaled analgesic products such as Penthrox, a fast-acting medication commonly used for pain relief in emergency settings. While effective for patients, exhaled vapours from these products may pose occupational health risks to paramedics due to limited ventilation and recirculating airflow within the ambulance cabin.

The project will also explore broader implications for airborne transmission of infectious agents—such as SARS-CoV-2 and influenza—within the ambulance environment.

The study will employ Computational Fluid Dynamics (CFD) modelling alongside experimental Particle Image Velocimetry (PIV) measurements to analyse airflow patterns, aerosol transport, and the associated exposure risks to paramedics.

Supervisory team

Dr Jingliang Dong, a Senior Lecturer and ARC DECRA Fellow at ISILC, Victoria University, has over 10 years of research experience in multiphase flow modelling, with a particular focus on respiratory airways. Dr Dong has authored over 100 publications in the field and was recently ranked in the top 0.5% globally in the specialty of the nasal cavity, according to ScholarGPS.

Associate Professor Brian Haskins, Discipline Lead of Paramedicine at the College of Sport, Health and Engineering, brings over 20 years of experience as an advanced paramedic, academic, and healthcare manager across Australia, the UAE, the US, and Ireland.

Together, their combined supervisory expertise will guide the candidate in developing best-practice strategies for managing the microenvironment within ambulances to safeguard the inhalation health of paramedics working on the front lines.

Supervisors: Dr Jingliang Dong, Associate Professor Brian Haskins
Institute: Institute for Sustainable Industries & Liveable Cities 
Course Code: UPAF
Field of Research (FoR) Code: 4003 Biomedical engineering

To indicate your interest and discuss your suitability, please contact: Dr Jingliang Dong,  [email protected]   

AI-powered frailty assessment: a multimodal system for quantitative gait & functional evaluation in older adults (RFO-25032)

This project focuses on developing an AI-powered, multimodal frailty assessment system to enable early detection and continuous monitoring of frailty in older adults. Leveraging computer vision and large language models (LLMs), the system will analyse video-captured movements, cognitive-linguistic tasks, and daily functional activities to produce quantitative health metrics. The research advances digital health innovation with potential applications in aged care, rehabilitation, and community-based healthcare settings.

The supervisory team offers strong expertise in AI, machine learning, digital health, and software engineering, and maintains active collaborations with clinical researchers and aged care providers. We are seeking a highly motivated PhD applicant with a background in computer science, biomedical engineering, or digital health. Ideal candidates will have experience in programming (e.g., Python, deep learning frameworks), a strong interest in human-centred AI, and a commitment to improving health outcomes through innovative and impactful technology.

Supervisors: Dr. Wenjie Ye, Professor Hong Xu, Professor Yuan Miao
Institute: Institute for Sustainable Industries & Liveable Cities
Course Code: UPAF
Field of Research (FoR) Code: 4602 Artificial intelligence

To indicate your interest and discuss your suitability, please contact: Dr. Wenjie Ye,  [email protected]   

Applied higher cognition & emotion (RFO-25101)

Our research focuses on innovating the assessment of human cognition and examining how cognitive factors influence everyday functioning. 

Our team has extensive experience in cognitive psychology and has published on topics including the interplay between higher-order cognition and emotional processing, the development of cognitive models that integrate affective dimensions, the relationship between emotional intelligence and personality with internalising symptoms such as anxiety, depression, and stress, the cognitive mechanisms underlying conspiratorial thinking, and the importance of the mind-body connection (embodied cognition and interoceptive sensibility) to health and wellbeing. These areas aim to advance understanding of the psychological processes that drive consequential behaviours. 

We are seeking applicants with a first-class honours degree in psychology, who are passionate about understanding the complexities of human cognition.

Supervisors: Professor Michelle Ball, Mr Stefan Sambol, Dr Jessica Scarfo
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 5201 Applied and developmental psychology

To indicate your interest and discuss your suitability, please contact: Professor Michelle Ball, [email protected]  

Appraising readiness for mental health specialty practice among undergraduate nurses (RFO-25060)

Mental health is one of the specialised areas of healthcare service that faces remarkable workforce challenges. So, it is essential to ensure that undergraduate nursing students undertaking mental health units and clinical placements are well-prepared prior to joining the mental health workforce to improve job satisfaction and provide best patient outcome. The more nursing students are equipped with mental health nursing theory, clinical placement, and simulation lab, the better the outcome in relation to how much they feel prepared and confident to provide best care for better patient outcome. 

This study, to be undertaken by a team of nurses with academic, acute and mental health expertise, will explore the readiness of undergraduate nursing students in joining mental health nursing workforce within their scope of practice and to identify factors that influence or hinder their smooth integration.

Supervisors: Dr Abdi Osman, Professor Gina Kruger
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4205 Nursing

To indicate your interest and discuss your suitability, please contact: Dr Abdi Osman,  [email protected]   

Brain signal modeling & platform development for brain state assessment (RFO-25033)

This project aims to develop an AI-based platform for brain state assessment through advanced modeling of brain signals, particularly electroencephalogram (EEG) data. It will focus on identifying and monitoring high-level brain functions such as attention, cognitive workload, relaxation, emotional states, and alertness. By combining adaptive mathematical modeling with deep learning and explainability techniques, the project will create interpretable and accurate models for real-time analysis of brain activity. The platform will support the development of intelligent monitoring tools capable of assessing alertness and cognitive states in real-world environments.

Expected outcomes include optimised brain signal models and a functional prototype platform. These innovations will support mental health monitoring, increase workplace efficiency, and strengthen safety in sectors like healthcare, transportation, and high-risk industries. The project will also drive progress in AI-based neurotechnology, delivering scalable and accessible tools to improve individual well-being and public safety.

Supervisors: Dr Siuly Siuly, Professor Hua Wang
Institute: Institute for Sustainable Industries & Liveable Cities 
Course Code: UPAF
Field of Research (FoR) Code: 4602 Artificial intelligence

To indicate your interest and discuss your suitability, please contact: Dr Siuly Siuly,  [email protected]   

Characterising and developing therapeutics for ultra-rare adenylosuccinate synthetase 1 myopathy (RFO-25034)

Adenylosuccinate synthetase 1 (ADSS1) myopathy is a progressive, debilitating, and life-threatening muscular disease that progresses from adolescence. Muscle weakness and wasting leads to loss of ambulation and swallowing in adulthood and cardiorespiratory complications, necessitating external assistance for daily activities. There is no cure or effective treatment. 

The project is developing the first indicated treatment for ADSS1 myopathy, directly targeting the biochemical defect in ADSS1 deficient muscles. Additionally, the project will characterise the molecular pathophysiology stemming from the biochemical defect to identify other potential drug targets. Through this project, we are addressing a significant gap in treatment options for this underserved population. 

Supervisors: Professor Emma Rybalka, Dr Cara Timpani
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 3209 Neurosciences

To indicate your interest and discuss your suitability, please contact: Professor Emma Rybalka,  [email protected]   

Co-designing a culturally responsive rehabilitation program for people with chronic respiratory diseases from culturally & linguistically diverse backgrounds (RFO-25035)

Rehabilitation is an essential component to effective management of chronic respiratory diseases. Yet people with chronic respiratory diseases rarely participate in rehabilitation. Even worse, people from culturally and linguistically diverse (CALD) backgrounds rarely participate in rehabilitation due to the lack of cultural responsiveness in the current programs. 

This project aims to use participatory action research methods to co-design a culturally responsive rehabilitation program for people from CALD communities. The applicant will be supported by a supervisory team who are experts in co-design methodologies and are well-connected with both health services, community programs and various CALD community groups. Potential applicant needs to be passionate about working with people from CALD backgrounds and have an understanding about the health service system in Australia.

Supervisors: Professor Clarice Tang, Professor Camilla Brockett
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Professor Clarice Tang,  [email protected]   

Cognitive & psychosocial outcomes in young adults with cerebral palsy (RFO-25036)

Cerebral Palsy (CP) is often considered a disorder of childhood, but it is a lifelong condition caused by a non-progressive brain disturbance affecting movement and posture. In addition to motor impairment, many people with CP experience cognitive impairments. While the brain injury is static, the cognitive and behavioural difficulties may evolve over time, particularly as young people transition into adulthood and face increasing demands for independence. 

This study aims to investigate the cognitive and behavioural functioning of young adults with CP, and how these factors influence psychosocial outcomes such as peer relationships and mental health. It builds and extends upon previous research by our group on adolescents with CP and provides an opportunity for a 10-year follow-up study.

We are seeking applicants who are Provisional Psychologists or Neuropsychologists with a strong interest in cognitive assessment.

Supervisors: Dr Darren Hocking, Dr Monika Coceski
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 5203 Clinical and Health Psychology

To indicate your interest and discuss your suitability, please contact: Dr Darren Hocking,  [email protected]   

Developing an explainable AI platform technology for early detection of dementia using brain signal data (RFO-25037)

This project aims to develop an explainable artificial intelligence (XAI)- assisted platform technology for the rapid, accurate, and automated detection of early-stage dementia—including its common forms such as Alzheimer’s disease—using brain signal data, particularly electroencephalogram (EEG) recordings. The platform will integrate advanced AI models with explainability techniques and modern data mining methods to effectively process and interpret large volumes of complex EEG data. 

Expected outcomes include a clinically relevant XAI-based diagnostic tool that supports healthcare professionals in early dementia detection, ultimately improving patient outcomes. This project will contribute to advances in health monitoring technologies and big data analytics, with the potential to reduce healthcare costs and enhance dementia care across Australia.

Supervisors: Dr Siuly Siuly, Professor Hua Wang
Institute: Institute for Sustainable Industries & Liveable Cities
Course Code: UPAF
Field of Research (FoR) Code: 4602 Artificial intelligence

To indicate your interest and discuss your suitability, please contact: Dr Siuly Siuly,  [email protected]   

Early detection & diagnosis of neurological disorders using non-linear analysis of gait data (RFO-25038)

This project will be supervised by Dr Dale Harris, Dr Nicholas Busuttil and Prof. Rezaul Begg. Dale has expertise in neurological rehabilitation, while Nicholas and Rezaul have experience in biomechanical analysis application to clinical gait biomechanics and inertial sensor integration. 

This project aims to apply non-linear analysis in the diagnosis and subsequent clinical decision-making for patients with neurological conditions such as Parkinson’s disease (PD). Technologies used in sport and workplace settings are increasingly accessible but lack the relevant precision and development required for early detection of PD. By combining wearable devices with advanced non-linear analysis techniques, this research will focus on identifying subtle, early-stage motor changes associated with gait-affected conditions, including early-onset PD. 

We are seeking an applicant with a passion for technology and an understanding of disease mechanisms to undertake a high-quality research project to improve health outcomes in neurological diagnosis and physical rehabilitation.

Supervisors: Dr Dale Harris, Mr Nicholas Busuttil; Professor Rezaul Begg
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Dr Dale Harris,  [email protected]   

Enhancing brain function & motor outcomes in Parkinson’s disease through combined neurostimulation and aerobic exercise therapies (RFO-25039)

This research is led by Dr Dale Harris and Dr Steven O’Bryan who are experts in neurophysiology with published research on neuromodulation and exercise prescription in Parkinson’s disease (PD).

This project investigates the combined therapeutic effects of photobiomodulation (PBM) and high-intensity aerobic exercise in people with PD. Aerobic exercise improves motor function, cardiovascular health, and neuroplasticity, while PBM - a commercially available, light-based therapy - targets mitochondrial function and neuroinflammation, key contributors to PD pathology. A series of studies will explore the feasibility, optimal dosage, and preliminary efficacy of an intervention combining aerobic exercise training with transcranial PBM applied to motor and cervical brain regions. 

Key outcomes include neuromuscular activation, inflammatory biomarkers, and motor function. The research will be conducted at Victoria University (VU) using advanced neuromuscular assessments alongside clinical motor evaluations. We seek an applicant passionate about combination therapies, including exercise, with an interest in understanding and improving outcomes in PD.

Supervisors: Dr Dale Harris, Dr Steven O'Bryan; Dr Nicholas Tripodi; Professor Alan Hayes
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Dr Dale Harris,  [email protected]   

 

Exploring mechanisms & treatments for muscle-wasting conditions (RFO-25040)

Primary myopathies such as Duchenne muscular dystrophy and the age-related loss of muscle mass and function as seen in sarcopenia have a common link – the destruction of muscle, heightened inflammation and poor regeneration, leading to fat and connective tissue infiltration, with subsequent decreased function and increased mortality. Muscle wasting also becomes a secondary driver of chronic diseases, and is now being increasingly seen with new weight loss drugs. Given loss of muscle also increases type 2 diabetes risk, and subsequent cardiovascular disease, maintaining and building skeletal muscle is imperative to healthy ageing and decreasing morbidity. While exercise is the obvious answer, not everyone can exercise, so adjunct treatments are needed.  

This project examines repurposed drugs, dietary supplements or new therapeutics in animal models and human participants to explore efficacy of use and mechanisms of action. The PhD candidate will have an interest and skills in tissue collection and laboratory investigation.

Supervisors: Professor Alan Hayes, Professor Itamar Levinger
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 3208 Medical Physiology

To indicate your interest and discuss your suitability, please contact: Professor Alan Hayes,  [email protected]   

Food & nutrition education for health: Interventions to improve knowledge, attitudes & practices (RFO-25041)

Diet is a key factor in disease prevention and management, and food also plays a significant role in the social and cultural wellbeing of individuals. Improving the food literacy of individuals through knowledge and skills development is key to the current and future health of the population. Similarly, improving nutrition literacy of health and care professionals will improve the quality of nutrition-related care provided by them.

The aims of this research are to:

• investigate the nutrition knowledge, attitudes and practices of different population cohorts, and the professionals who interact with them
• determine strategies to improve knowledge, attitudes and skills;
• co-design, deliver and evaluate interventions.

Our research team has expertise in public health nutrition, nutrition education and food literacy. This research would suit applicants with a background in nutrition and/or health with a passion for improving nutrition literacy and health.

Supervisors: Associate Professor Helen McCarthy, Dr Lannie O'Keefe; Prof Andrew McAinch; Dr Tafadzwa Nyanhanda
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 3210 Nutrition and Dietetics

To indicate your interest and discuss your suitability, please contact: Associate Professor Helen McCarthy,  [email protected]   

Gender inequality & women as agents of change (RFO-25042)

This research stream aims to improve intersectional understandings of normative femininities across sociocultural contexts and settings and the impacts on young women’s and women’s psychosocial wellbeing. 

The accompanying aim of this work is to understand young women’s and women’s experiences of and responses to inequality and the ways in which they engage in social change and leadership. The research team includes Dr Romana Morda and Dr Linda Chiodo, PhD candidates and Honours students. Projects have applied a gendered lens to exploring leadership and critical consciousness development, mental health help seeking and the safety of women online. They have also explored the experiences of women of colour in navigating family and work roles and commitments. 

The focus of future projects will be to extend on this work by critically examining the lived experiences of women from socially and culturally diverse communities and their negotiations of normative femininities and expectations.

Supervisors: Dr Romana Morda, Dr Linda Chiodo
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 5205 Social and personality psychology

To indicate your interest and discuss your suitability, please contact: Dr Romana Morda,  [email protected]   

Gendered unpaid work: it's impact on employee wellbeing (RFO-25043)

This PhD project investigates how the gendered distribution of unpaid household labour impacts individual wellbeing and work-related outcomes, particularly in the context of hospitality and tourism. The study will explore potential shifts in unpaid labour patterns following the COVID-19 pandemic and their implications for personal and professional wellbeing.

The research team comprises academics with expertise in wellbeing, gender studies, and the hospitality and tourism sectors. We are seeking a motivated PhD applicant with strong research skills, a background in human resource management, gender studies, or social sciences, and an interest in the intersection of work, wellbeing, and domestic life. Quantitative and/or qualitative research experience will be an advantage.

Supervisors: Dr Dharshani Thennakoon, Dr Thu-Huong Nguyen
Institute: Institute for Sustainable Industries & Liveable Cities
Course Code: UPAF
Field of Research (FoR) Code: 3507 Strategy, management and organisational behaviour

To indicate your interest and discuss your suitability, please contact: Dr Dharshani Thennakoon,  [email protected]   

Human-caused disaster prevention & intervention (RFO-25102)

Our team focuses on the prevention of deliberate human-caused community disasters, and the subsequent negative impacts on individual and community health and wellbeing. Our work aims to improve the early identification of people at risk of engaging in behaviour with potentially catastrophic consequences for themselves, others and society (e.g. firesetting, violent extremism, conspiratorial thinking) to assist in informing needs-based prevention and intervention. 

Our team works closely with industry partners and Government agencies (e.g. Australian fire and rescue services) and has been involved in the design and development of evidence-based prevention and intervention programs, protocols, and resources. Our work is done through a psychological lens and potential applicants will hold a first class Honours in Psychology.

Supervisors: Professor Michelle Ball, Dr Kara Dadswell, Mr Stefan Sambol
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 5201 Applied and developmental psychology

To indicate your interest and discuss your suitability, please contact: Professor Michelle Ball, [email protected]  

Improving access to cancer rehabilitation through community-based rehabilitation programs (RFO-25044)

Cancer rehabilitation is an integral component to improving survivorship among people with cancers. However, access to cancer rehabilitation are currently limited, with majority of services catered for adults living with cancer and limited to the hospital settings. Cancer rehabilitation for children remained to be scarce and largely dependent on the hospital settings to provide rehabilitation programs. There is an urgent need to look at innovative ways to introduce community-based cancer rehabilitation for all people with cancer. 

The research team will bring forth expertise in the area of exercise and rehabilitation to support potential applicant in exploring innovative ways to improve access of cancer rehabilitation within the community settings. In addition, the research team is well connected to both health services and community services who can provide expertise and access to facilities to implement cancer rehabilitation programs. Potential applicant must have a passion in rehabilitation programs and a desire to work with people with cancers, including children.

Supervisors: Professor Clarice Tang, Professor Camilla Brockett
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Professor Clarice Tang,  [email protected]   

Integrating health & social care to improve health and reduce preventable hospitalisations in disadvantaged & rural communities (RFO-25103)

This research program is to test and evaluate social prescribing as a component of clinical healthcare in a rural community. It aims to address and mitigate the adverse impacts of the social determinants of health on health and wellbeing by implementing a more holistic approach to care and prevention in collaboration between health services in a rural city and Victoria University’s Health Policy team.

The implementation will bring together a collaborative network of health services and community organisations to deliver an innovative social prescribing program addressing the social and other factors that affect the health and wellbeing of individuals who are frequent users of health services. The design of the program is based on the extensive research undertaken by the health policy team for the Commonwealth Health Department. The implementation will be tailored using co-design approach with community organisations and members. The applicant needs to be interested in mixed-method research.

Supervisors: Dr Jerome Rachele, Professor Maximilian de Courten; Professor Rosemary Calder
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4203 Health services and systems

To indicate your interest and discuss your suitability, please contact: Dr Jerome Rachele, [email protected]   

Interrogating the mechanisms of the microbiome to muscle signalling in muscle wasting disease (RFO-25045)

Duchenne muscular dystrophy is an incurable muscle wasting disease with limited treatment options. The disease is fatal, and sufferers ultimately succumb to cardiorespiratory failure in their mid-twenties. New and effective therapeutic interventions are of the essence. Emerging evidence suggests that gut microbiota play a crucial role in maintaining muscle health and our preliminary data demonstrates that targeting the microbiota, through restoration of a healthy microbiota profile, attenuates deficits in muscle function and quality in a mouse model of Duchenne muscular dystrophy. The mechanisms driving these benefits to skeletal muscle are unknown and will be crucial to discover to progress integration into clinical management. 

This research project will uncover these mechanisms and illuminate novel, modifiable targets for therapeutic development. Importantly, the findings of this research will be far-reaching and could impact other rare, poorly treated muscle wasting diseases including ADSS1 myopathy, ALS and Limb Girdle muscular dystrophy.

Supervisors: Professor Emma Rybalka, Dr Cara Timpani
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 3209 Neurosciences

To indicate your interest and discuss your suitability, please contact: Professor Emma Rybalka,  [email protected]   

Investigating novel therapeutics to target autophagy as a therapeutic strategy for cancer treatment (RFO-25104)

This research aims to identify and develop novel therapeutic agents that modulate autophagy pathways as a targeted strategy for cancer treatment. Autophagy, a highly regulated cellular process responsible for degrading and recycling damaged cellular components, plays a complex role in cancer. While it can suppress tumour initiation by removing damaged organelles and proteins, in established cancers, autophagy supports tumour cell survival under stress conditions, such as hypoxia and nutrient deprivation. This research will identify and characterise therapeutic compounds that inhibit or enhance autophagy, depending on the cancer context. 

Using in vitro cancer cell models, the therapeutic potential of these agents will be evaluated based on their ability to modulate autophagic flux, influence cell survival, and enhance the sensitivity of cancers to existing chemotherapies. 

Insights gained from this study may contribute to the development of more precise and effective cancer treatments by leveraging autophagy as a novel and exploitable target.

Supervisors: Professor John T Price, Dr Charlett Giuliani
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 3101 Biochemistry and Cell Biology

To indicate your interest and discuss your suitability, please contact: Professor John T Price, [email protected]  

Investigating the role of transport infrastructure in neighbourhood socioeconomic health inequities (RFO-25046)

This project investigates how transport infrastructure contributes to neighbourhood-level socioeconomic health inequities by shaping access to the social determinants of health, such as employment, education, healthcare, and social connection. Despite growing recognition of neighbourhood design as a determinant of health, substantial evidence gaps remain regarding how these environmental factors contribute to health inequalities. 

This project will use geospatial analysis and linked longitudinal data to generate new evidence on how transport systems perpetuate or reduce health disparities. By identifying spatial patterns of transport disadvantage and their health implications, the research will enhance understanding of the structural drivers of inequity. The findings will inform more equitable approaches to urban planning and public health policy, supporting better-targeted infrastructure investment and improved health outcomes for socioeconomically disadvantaged communities.

Supervisors: Dr Jerome Rachele, Dr Venurs Loh
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4206 Public Health

To indicate your interest and discuss your suitability, please contact: Dr Jerome Rachele,  [email protected]   

Investigation of the role of lncrnas in the stress transcriptional response in cancer metastasis (RFO-25105)

Cancer metastasis, the spread of cancer from its original site of growth to a distant organ, is the leading cause of cancer-related deaths, highlighting the importance of understanding the mechanisms driving metastatic progression. The biological impact of long non-coding RNA (lncRNA) in cancer metastasis is emerging. However, their role in the transcriptional stress response pathway, a key driver of the metastatic phenotype, has yet to be determined. 

This research will examine specific lncRNAs and their role in modulating or being modulated by cellular stress pathways within metastatic cells from pancreatic, breast, lung, melanoma and glioma cancers. Specifically, this research will evaluate the interaction and regulation of lncRNAs of stress transcription factors such as Heat Shock Factor 1 and vice-versa, characterising the role that this regulation has on promoting/inhibiting cancer metastasis. 

Results from this research will help uncover novel therapeutic targets leading to potential novel clinical metastatic treatments in the future.

Supervisors: Professor John T Price, Dr Charlett Giuliani
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 3101 Biochemistry and Cell Biology

To indicate your interest and discuss your suitability, please contact: Professor John T Price, [email protected]  

Investigation of brachial artery stiffness effects on hemodynamics in diabetic patients using fluid-structure interaction & particle image velocimetry (RFO-25047)

This research project aims to develop a multiphysics model of arterial blood flow in both healthy individuals and diabetic patients with varying levels of arterial stiffness. The PhD candidate will collaborate with clinical doctors and utilise existing clinical data from diabetic patients. Through the supervisory team’s research partnerships, the project will access realistic ultrasound, CT, or MRI data to simulate haemodynamic conditions using a fluid-structure interaction (FSI) approach. The model will be validated using Particle Image Velocimetry (PIV) to account for arterial wall compliance. 

This research will provide valuable insights into the mechanical behaviour of arteries under different physiological conditions and improve understanding of cardiovascular risk in diabetic patients.

Supervisors: Dr Jingliang Dong, Professor Itamar Levinger
Institute: Institute for Sustainable Industries & Liveable Cities  
Course Code: UPAF
Field of Research (FoR) Code: 4003 Biomedical engineering

To indicate your interest and discuss your suitability, please contact: Dr Jingliang Dong,  [email protected]   

Musculoskeletal health, quality of life and its social determinants in middle age (RFO-25048)

The population is ageing, and thus the focus in healthcare needs to shift to improving quality of life and health rather than only treating disease and delaying mortality. In this WHO Decade of Healthy Ageing, post-Covid there is a concern that poor musculoskeletal health is occurring at earlier ages, and along with other diseases is leading to poor quality of life at earlier life stages.

This prospective study aims to investigate musculoskeletal health in middle aged adults to determine the incidence and risk of osteoporosis and sarcopenia, and determine the physical, biological, social and lifestyle factors that are contributing to these conditions across the west of Melbourne. 

Supervised by Professor Alan Hayes, Professor Itamar Levinger and Associate Professor Fiona McLachlan, the PhD candidate will organise self and others, be able to build and maintain relationships and have an interest and skills in quantitative and qualitative data analysis.

Supervisors: Professor Alan Hayes, Professor Itamar Levinger, Associate Professor Fiona McLachlan
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 4206 Public Health

To indicate your interest and discuss your suitability, please contact: Professor Alan Hayes,  [email protected]   

Numerical & experimental study of aerosol transport & absorption in respiratory airways (RFO-25050)

This PhD project aims to advance our understanding of aerosol transport and absorption in the upper respiratory tract, with a focus on nasal inhalation exposure in laboratory rats. The study integrates numerical modelling, experimental flow visualisation, and in vivo biological validation to investigate how inhaled agents navigate complex airway geometries and potentially reach brain tissues through olfactory pathways. The findings will contribute to the development of non-invasive drug delivery methods targeting the central nervous system, offering potential therapeutic strategies for neurodegenerative diseases such as dementia and Alzheimer's disease.

Dr Jingliang Dong, a Senior Lecturer and ARC DECRA Fellow at ISILC, Victoria University, has over 10 years of research experience in multiphase flow modelling, with a particular focus on respiratory airways. Dr Dong has authored over 100 publications in the field and was recently ranked in the top 0.5% globally in the specialty of the nasal cavity, according to ScholarGPS.

We are looking for a motivated PhD candidate with a background or strong interest in fluid dynamics, computational modeling, biomedical engineering, or related fields. Experience in veterinary science or animal physiology is a plus but not essential. The ideal candidate should be eager to learn, collaborate across disciplines, and communicate effectively with both academic and industry partners.

Supervisors: Dr Jingliang Dong, Lannie O'Keefe
Institute: Institute for Sustainable Industries & Liveable Cities
Course Code: UPAF
Field of Research (FoR) Code: 4003 Biomedical engineering

To indicate your interest and discuss your suitability, please contact: Dr Jingliang Dong,  [email protected]   

Nutrition for sports performance & health (RFO-25051)

This project area will investigate the effects of different nutritional strategies and supplements for the enhancement of sports performance and health. Understanding how our body recovers and adapts from exercise bouts and thus how to best take full advantage of nutritional interventions to enhance recovery is essential to maximise performance. However, these same interventions can also be used to understand the role of various nutritional interventions to improve health throughout the lifespan. 

This project area will involve projects that utilise applied sports dietetics and/or molecular work to investigate novel food ingredients and supplemental strategies in both human and animal models to determine changes in various performance, health and molecular markers.  Projects suitable for nutrition, exercise and/or biomedical students.

Supervisors: Professor Andrew McAinch, Professor Alan Hayes, Professor Michael Mathai
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 3210 Nutrition and dietetics

To indicate your interest and discuss your suitability, please contact: Professor Andrew McAinch,  [email protected]   

Optimising effective multidisciplinary team care in general practice for healthy ageing (RFO-25106)

As care for the ageing population becomes increasingly complex, general practice must evolve toward team-based models of care. Multidisciplinary teams (MDTs) have demonstrated promise in improving care coordination, patient outcomes, and workforce satisfaction. However, evidence remains limited on how best to implement and sustain MDTs in diverse primary care settings to promote healthy ageing and delay chronic age-related diseases and conditions. 

This mixed-methods study will identify effective MDT models, assess implementation factors, and co-develop a best-practice framework with stakeholders. Findings will guide general practices, allied health services and policymakers in establishing sustainable MDTs to improve quality and equity in care delivery for the ageing population. 

The applicant must be interested in multi-disciplinary research, mixed-methods, health service implementation and research translation.

Supervisors: Dr Jerome Rachele, Professor Maximilian de Courten; Professor Rosemary Calder
Institute: Institute for Health & Sport              
Course Code: UPAD
Field of Research (FoR) Code: 4203 Health services and systems

To indicate your interest and discuss your suitability, please contact: Dr Jerome Rachele, [email protected]   

Post-stroke gait rehabilitation using an ankle assistive device to prevent falls (RFO-25052)

Falling risk is 150% higher in stroke survivors compared to age-matched controls. The principal cause of falls is tripping. This research topic will employ research in clinical gait biomechanics, artificial intelligence (AI) and powered exoskeletons to provide a technology-based solution to stroke rehabilitation and falls prevention. This project would be ideally suited to a student with a background in biomechanics, physiotherapy, health sciences, computer science or engineering. 

The aim is to develop and test an innovative falls prevention device that will lift the foot during the gait cycle’s swing phase to increase ground clearance and, consequently, reduce tripping risk. 

The PhD program will be supervised by a multidisciplinary team: Prof Rezaul Begg with globally recognized expertise in gait and posture biomechanics, machine learning, and assistive technology applications; Dr Hanatsu Nagano with a specialisation in biomechanics and exoskeleton technology, and Dr Assefa Teshome in AI/machine learning, robotics and sensors.

Supervisors: Professor Rezaul Begg, Dr Assefa Teshome, Dr Hanatsu Nagano
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Professor Rezaul Begg,  [email protected]  

Promoting resilience, wellbeing & community connectedness in vulnerable groups (RFO-25053)

Our research addresses the ways in which masculinity, identity, and context impact community health. This is achieved through innovative research, strong partnerships, and placed based action in the northwest of Victoria. We co-develop research understandings, frameworks, and programs to address social inclusion, homelessness, addiction, and sustainable healthy lifestyle choices. Our research is embedded in our local communities where we develop partnerships and advocate for community based programs.

Supervisors: Associate Professor Peter Gill, Dr Lutfiye Ali, Dr Romana Morda, Dr Andrew Jago, Dr Linda Chiodo, Dr Amy Quayle
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 5299 Other psychology

To indicate your interest and discuss your suitability, please contact: Associate Professor Peter Gill,  [email protected]   

Quantum AI for detection of speech & language needs in youth mental health (RFO-25054)

This project explores the use of Classical and Quantum Natural Language Processing (QNLP) to develop semantic models for early detection of Speech, Language, and Communication Needs (SLCN) in youth, a key factor contributing to Behavioural, Emotional, and Social Difficulties (BESD). Leveraging both The New York Times corpus and CLARE’s longitudinal datasets, the project uses the ‘lambeq’ quantum NLP library to calculate semantic density. We aim to build scalable, affordable tools for screening SLCN in English and Hindi. 

The research team includes experts in AI, quantum computing, NLP, and speech pathology across Australia and India. We seek a highly motivated HDR applicant with a strong background in AI, NLP, and/or quantum computing and an interest in interdisciplinary research with clinical and social impact.

Supervisors: Associate Professor Khandakar Ahmed, Dr Wenjie Ye, Dr Assefa Teshome
Institute: Institute for Sustainable Industries & Liveable Cities
Course Code: UPAF
Field of Research (FoR) Code: 4602 Artificial Intelligence

To indicate your interest and discuss your suitability, please contact: Associate Professor Khandakar Ahmed,  [email protected]   

Smart exoskeletons for back injury prevention (RFO-25055)

Manual handling injuries, especially to the lower back, account for nearly 40% of workplace incidents in Australia, imposing over $28 billion in annual costs. 

This research project will develop a wearable exoskeleton to protect workers from unexpectedly heavy loads by augmenting an upper body exoskeleton with real-time, predictive, Artificial Intelligence (AI) control. The device will provide pre-emptive support to reduce injury risk and enhance workplace safety, leading to improved designs for commercially viable upper-body exoskeletons.  

This project would be ideally suited to a student with a background in biomechanics, physiotherapy, health sciences, computer science or engineering.  

The PhD program will be supervised by a multidisciplinary team of Prof Rezaul Begg with globally recognised expertise in gait and posture biomechanics, machine learning, and assistive technology applications, Dr Alessandro Garofolini with a specialization in predictive biomechanics and exoskeleton technology, and A/Prof Khandakar in AI/machine learning.

Supervisors: Professor Rezaul Begg, A/Prof Khandakar Ahmed, Dr Alessandro Garofolini
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Professor Rezaul Begg,  [email protected]   

Supporting parent–infant communication in the neonatal intensive care unit (RFO-25056)

This project develops and pilots a structured, parent-led communication program to support early language development for neonates admitted to the NICU. Grounded in developmental and communicative frameworks, it empowers parents with practical strategies for engaging in language-rich interactions, enhancing infant outcomes and parental bonding. The program’s clinical relevance, feasibility, and acceptability will be evaluated by NICU professionals. By integrating communication into existing care models, the research aims to improve family-centered NICU practices, reduce parental stress, and contribute to long-term developmental gains in preterm infants. Findings will inform clinical guidelines and promote holistic, inclusive care in neonatal settings.

This project holds significant clinical, developmental, and psychosocial value. It addresses a critical gap in neonatal intensive care by empowering parents to actively support their infant’s early communication development which is often overshadowed by medical priorities in the NICU.

Supervisors: Dr Bianca Jackson, Dr Caglayan Yasan, Dr Romana Morda
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 5201 Applied and developmental psychology

To indicate your interest and discuss your suitability, please contact: Dr Bianca Jackson,  [email protected]   

The role of nutrition & exercise in women’s health (RFO-25057)

This project area focuses on the role of nutrition and exercise in women’s health, specifically Polycystic ovary syndrome (PCOS) and pregnancy. PCOS affects ~1 million Australian women. Insulin resistance is implicated as a key driver for many complications in PCOS. Understanding how nutrition and exercise improve health in women with PCOS and to understand the molecular signalling associated with this improvements will be investigated. Optimal nutrition during pregnancy is crucial for foetal development and women’s health. We have established through animal studies that dietary fatty acids have an impact on the outcomes of pregnancy and health of the offspring. 

This research area will provide opportunities in understanding the effects of various lifestyle factors (including diet and exercise) during pregnancy in humans and the potential molecular signalling associated with these interventions. 

This research area has strong collaborations across multiple Universities and hospitals. Projects suitable for nutrition, exercise and/or biomedical students.

Supervisors: Professor Andrew McAinch, Dr Rhiannon Patten, Dr Lannie O'Keefe, Associate Professor Deanne Hryciw (Griffith Uni) and/or Professor Ray Rodgers (Uni of Adelaide)
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 3210 Nutrition and dietetics

To indicate your interest and discuss your suitability, please contact: Professor Andrew McAinch,  [email protected]   

The role of nutrition in osteoarthritis prevention & management (RFO-25058)

ne of the greatest risk factors for Osteoarthritis (OA), is an increased body weight and decreased muscle mass. Not only is the risk of developing OA elevated with increasing body weight, but also increases the risk of elevated pain, disability, and overall complications, after OA surgery. 

There is little information regarding the nutritional risk factors in OA, other than recommended weight loss for those awaiting orthopaedic surgery, which can be problematic due to decreased mobility and physical activity. Understanding the weight history and nutritional profile of people with OA and then implementing targeted interventions suitable for diverse populations groups to improve bone health and clinical outcomes is essential to improve long term health of people living with OA. 

This applied research will be conducted in collaboration with Western Health. Projects suitable for nutrition and dietetic trained students.

Supervisors: Professor Andrew McAinch, Dr Lannie O'Keefe
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 3210 Nutrition and dietetics

To indicate your interest and discuss your suitability, please contact: Professor Andrew McAinch,  [email protected]   

The role of sex hormones in neural, skeletal, and musculotendinous ageing (RFO-25059)

Physical function declines earlier in life for females compared to males. This project will explore the role of sex hormones in this dimorphic response and extend on our previous work in ageing females, focusing on neural, skeletal and musculotendinous structure and function. The influence of other factors such as exercise training, hormone replacement therapies, contraceptive use or diet can also be explored based on the applicant’s interests.

The multi-disciplinary project will be led by Dr O’Bryan (neuromuscular physiologist) and supported by Dr Harris (exercise physiologist) and Prof. Levinger (clinical physiologist), with all members demonstrating a successful track record in supervising research students, securing competitive research funding and publishing in high-quality international journals. We seek a highly motivated and passionate applicant with an interest in neuromuscular physiology, endocrinology and gerontology.

Supervisors: Dr Steven O'Bryan, Dr Dale Harris, Professor Itamar Levinger
Institute: Institute for Health & Sport              
Course Code: UPAD
Field of Research (FoR) Code: 3202 Clinical sciences

To indicate your interest and discuss your suitability, please contact: Dr Steven O'Bryan,  [email protected]   

Therapeutic efficacy of krill oil on inflammatory bowel disease (RFO-25049)

Inflammatory bowel disease (including ulcerative colitis and Crohn’s disease) is a chronic gastrointestinal tract disorder, and there is no curative treatment. Current therapies are often ineffective or associated with significant adverse effects. Krill oil is a rich source of long-chain omega-3 polyunsaturated fatty acids and antioxidants, astaxanthin. Its potential therapeutic properties in a range of chronic disease, and in the prevention of acute colitis (animal models) have gained increasing attention.

Our research has shown that krill oil can alleviate chronic colitis symptoms and restore gut functions. Further research will focus on molecular signalling pathways associated with the potential therapeutic roles of krill oil using Next-Generation Sequencing and Wester Blotting techniques. Winnie murine model, a model closely resembling human IBD will be used. Furthermore, the impact of krill oil treatment on body composition, food intake and energy expenditure of Winnie mice will be investigated using Echo MRITM and the Promethion system. 

Supervisors: Associate Professor Xiao Su, Professor Kulmira Nurgali
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 3208 Medical Physiology

To indicate your interest and discuss your suitability, please contact: Associate Professor Xiao Su,  [email protected]   

Understanding health influencer credibility & homophily in shaping consumer behavior & well-being (RFO-25107)

The proposed research seeks to examine how the perceived credibility and homophily (similarity) of health influencers drive consumer mimicry, shape consumer behavior, and affect consumer well-being. By combining insights from psychological and consumer behavior theories, the study aims to explore how consumers understand influencer messages and adopt behaviors, and how this ultimately influences their well-being. 

The project will be led by Dr Thu-Huong Nguyen from Victoria University, Melbourne, and Prof. Ruchi Gupta from University of Delhi, India (VU registered supervisor), who bring rich experience in marketing, consumer behaviour and wellbeing, influencer marketing and digital marketing. Together, they offer an ideal mix of global insight and research depth. 

We welcome applications from enthusiastic Ph.D. candidates who have a strong interest in influencer marketing, consumer behavior, and digital marketing. The ideal applicants will have a background in marketing and/or behavioral science, with a keen interest in theory-driven, empirical research. 

Supervisors: Dr Thu-Huong Nguyen, Professor Ruchi Gupta
Institute: Institute for Sustainable Industries & Liveable Cities 
Course Code: UPAF
Field of Research (FoR) Code: 3507 Strategy, management and organisational behaviour

To indicate your interest and discuss your suitability, please contact: Dr Thu-Huong Nguyen, [email protected]   

Understanding the role of bone in muscle mass, strength & metabolism as well as the effect of exercise on on bone and muscle with implications to cardio-metabolic diseases (RFO-25061)

between men and women. In addition, the mechanisms of action of bone peptides in muscle is largely unknown. This project aims to uncover whether the bone peptides function in muscle is sex and/or age specific. 

This project will lead to a better understanding of the molecular mechanisms of bone-muscle interaction and the functional and clinical implications of such interaction. The benefits of this include the development of future health interventions to improve muscle mass and strength so Australians can age healthier.

Supervisors: Professor Itamar Levinger, Professor Alan Hayes
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Professor Itamar Levinger,  [email protected]   

Upskilling Australia’s health workforce to provide safe care for people experiencing body dissatisfaction & related concerns (RFO-25108)

This project offers an opportunity to improve Australian healthcare professionals’ skills, knowledge, and confidence to provide safe and evidence-informed care to people seeking support for body dissatisfaction and related concerns. This project seeks to: 

1. Deliver training to health care professionals including psychologists, psychiatrists, dietitians and general practitioners; and evaluate its impact upon participants’ adoption of best-practices for supporting people with body dissatisfaction and related concerns.

2. Use implementation science principles to assist in designing Australia-wide rollouts of this training

3. Understand the long-term impact of this training on weight stigma of health professionals and eating and body related wellbeing of the public.

Supervisors: Dr Jo Doley, Dr Helen McCarthy, Dr Linda Chiodo
Institute: Institute for Health & Sport 
Course Code: UPAD
Field of Research (FoR) Code: 5203 Clinical and health psychology

To indicate your interest and discuss your suitability, please contact: Dr Jo Doley, [email protected]   

Virtual real-time AUSLAN interpreter; SL-AVATAR (RFO-25062)

This project aims to develop a virtual real-time Auslan interpreter (SL-AVATAR) to support communication for the Australian deaf community. SL-AVATAR will use AI, Natural Language Processing, and a custom-built sign language database to interpret English speech and text into Auslan in real time, via an expressive 3D avatar. Our multidisciplinary team includes experts in AI, linguistics, and accessibility, with collaborators from Deaf Victoria and La Trobe University. 

We seek an HDR candidate passionate about AI for social good, with strong technical skills in machine learning and/or NLP. The candidate will contribute to developing the NLP pipeline and assist in user testing with community partners. 

This project offers a unique opportunity to work on inclusive technology with real-world impact.

Supervisors: Associate Professor Khandakar Ahmed, Dr Wenjie Ye, Professor Yuan Miao, Dr Ayman Ibaida
Institute: Institute for Sustainable Industries & Liveable Cities
Course Code: UPAF
Field of Research (FoR) Code: 4602 Artificial Intelligence

To indicate your interest and discuss your suitability, please contact: Associate Professor Khandakar Ahmed,  [email protected]   

Youth-led solutions to shift from car to active travel (RFO-25063)

Despite physical activity in youth being critical for healthy development, just 1 in 10 Australian youth meet the national physical activity guidelines. Increasing active travel, such as walking and cycling, is an effective strategy to increase physical activity. 

This project will identify the environmental supports and behaviour change strategies needed to encourage active travel in partnership with youth and other relevant stakeholders. Specifically, it will work with youth as citizen scientists to identify barriers to active travel and advocate for improvements in their neighbourhood infrastructure. Urban design solutions and behaviour change strategies will be identified via participatory approach to produce a ready-to-implement intervention promoting active travel.

Supervisors: Dr Venurs Loh, Dr Jerome Rachele
Institute: Institute for Health & Sport
Course Code: UPAD
Field of Research (FoR) Code: 4206 Public Health

To indicate your interest and discuss your suitability, please contact: Dr Venurs Loh,  [email protected]   

Exercise and Mitochondria Biogenesis (RFO-25121)

Mitochondria are critical organelles that transform energy from breathed oxygen and ingested nutrients, powering skeletal muscle contraction and human performance. 

However, mitochondria also have several life-sustaining functions beyond energy transformation, which make them critical for good health and healthy ageing. 

A defining aspect of these dynamic organelles is their remarkable plasticity, which allows them to sense, respond, and adapt to various stressors. 

In particular, it is well established that the stress of exercise provides a powerful stimulus that can trigger transient or enduring changes to a wide range of mitochondrial characteristics. This makes it important to understand the optimal prescription (i.e., type, dose, frequency, duration etc) to improve mitochondrial content and function. 

In this PhD project, we will evaluate how different exercise prescription variables influence mitochondrial adaptations to training.

Supervisors: Professor David Bishop, Dr Nicholas Saner, Dr Dale Taylor
Institute: Institute for Health and Sport
Course code: UPAD
Field of Research (FoR) code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Professor David Bishop,  [email protected]  

Effects of intermittent hypoxia exposure and exercise on glucose metabolism in muscle and adipose tissue of individuals with pre-diabetes (RFO-25122)

The primary objective of this study is to compare the effects of a 4-week high-intensity interval training (HIIT) program with a 4-week intermittent hypoxia exposure program on glycaemic control and tissue-specific glucose metabolism (in muscle and adipose tissue) among overweight individuals with pre-diabetes.

A total of 30 overweight or obese males and females, aged 35–55 years (15 with pre-diabetes and 15 without), will be recruited. Participants will undergo either a 4-week intermittent hypoxia intervention (14.1% oxygen, equivalent to 3,200 m altitude) or a 4-week HIIT intervention. Following a 3-month washout period, participants will cross over to complete the alternate intervention.

Muscle and adipose tissue biopsies will be collected to assess glucose metabolism. In addition, an oral glucose tolerance test (OGTT) will be conducted before and after each intervention, with venous blood samples collected during the OGTT for glucose and related biomarker analyses.

Supervisors: Associate Professor Sean Yan, Professor Itamar Levinger
Institute: Institute for Health and Sport
Course code: UPAD
Field of Research (FoR) code: 4207 Sports science and exercise

To indicate your interest and discuss your suitability, please contact: Sean Yan,  [email protected]