This unit builds upon the basic synthetic chemistry covered in NPU2103 Organic Synthesis with a clear focus on the techniques used in the synthesis of modern pharmaceutical products. Important synthetic methodologies for the preparation of chiral compounds are emphasised including an introduction to bio-catalysis. Modern spectroscopic and spectrometric techniques are further utilised in this unit.

Unit details

Study level:
Undergraduate
Credit points:
12
Unit code:
NPU3103

Prerequisites

NPU2103 - Organic Synthesis

Learning Outcomes

On successful completion of this unit, students will be able to:
  1. Apply and explain the principles of various organic synthetic procedures to drug synthesis;  
  2. Categorise the different classes of protecting groups and describe their role in organic synthesis;  
  3. Evaluate various chiral synthetic methodologies, including bio-catalysis, and their application to drug synthesis;  
  4. Articulate the principles and application of combinatorial synthesis;  
  5. Adapt common practical organic chemistry manipulations and interpret various analytical data including infra-red and nuclear magnetic resonance spectra, in collaboration with others and with responsibility for own output; and  
  6. Evaluate the quality of their own synthesised products and related analytical data and report the findings to peers and demonstrators with initiative and judgement.  

Assessment

Assessment type Description Grade
Assignment Short Answer Assignment (1000 word equivalent) 10%
Laboratory Work Portfolio of Laboratory work with summary addressing criteria (1500 words) 45%
Examination Final Exam (2 hours) 45%
Laboratory work and the development of practical skills are a critical component of this Unit. Students must therefore attend all of the laboratory sessions and as the laboratory sessions are a critical part of the Learning Outcomes (5,6) of this Unit, a student MUST pass the laboratory component in order to pass the Unit.

Required reading

Organic Chemistry 9th ed.
McMurry, J.E., (2016)
Cengage

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