Section: Overview
Key publications
Research funding
Supervising & teaching

Key details

Areas of expertise

  • Epigenetics and exercise response
  • Exercise/muscle physiology
  • Genetics and adaptation to training in health and disease

Available to supervise research students

Not available for media queries

About Danielle Hiam

Danielle is an emerging early career researcher at the Institute for Health and Sport at Victoria University. She is a postdoctoral fellow in the Genetics and Epigenetics of Exercise group, which aims to identify genes and molecular mechanisms (e.g. epigenetics) that contribute to the variable responses to similar exercise training and the ageing processes.

She completed her PhD at Victoria University in October 2018 where she interrogated the role of epigenetics in the aetiology of Polycystic Ovary Syndrome. Danielle’s research interests involve understanding sex-specific genetic and epigenetic differences in response to exercise in the Human gene SMART study. She has 19 published papers, including first authorship papers in leading Ageing and Epigenetics Journals. She is the seminar convener for the Institute for Health and Sport, and a council member in the Australia Physiological Society (AuPS).


  • PhD, Victoria University, Australia, 2018
  • Bachelor of Exercise and Sport Science, Deakin University, Australia, 2010
  • Bachelor of Biomedical Science, Deakin University, Australia, 2009

Key publications

Year Citation
2020 Hiam, D., Smith, C., Voisin, S., Denham, J., Yan, X., Landen, S., Jacques, M., Alvarez-Romero, J., Garnham, A., & Woessner, M. N. (200115). Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan. Aging, 12(1), (359-369).

doi: 10.18632/aging.102627

2020 Smith, C., Voisin, S., Al, Saedi., Phu, S., Brennan-Speranza, T., Parker, L., Eynon, N., Hiam, D., Yan, X., & Scott, D. (200101). Osteocalcin and its forms across the lifespan in adult men. Bone, 130

doi: 10.1016/j.bone.2019.115085

2019 Hiam, D., Simar, D., Laker, R., Altlnta, A., Gibson-Helm, M., Fletcher, E., Moreno-Asso, A., Trewin, A. J., Barres, R., & Stepto, N. K. (191201). Epigenetic Reprogramming of Immune Cells in Women with PCOS Impact Genes Controlling Reproductive Function. Journal of Clinical Endocrinology and Metabolism, 104(12), (6155-6170).

doi: 10.1210/jc.2019-01015

2019 Hiam, D., Moreno-Asso, A., Teede, H. J., Laven, J. SE., Stepto, N. K., Moran, L. J., & Gibson-Helm, M. (191001). The Genetics of Polycystic Ovary Syndrome: An Overview of Candidate Gene Systematic Reviews and Genome-Wide Association Studies. JOURNAL OF CLINICAL MEDICINE, 8(10),

doi: 10.3390/jcm8101606

2019 Jacques, M., Hiam, D., Craig, J., Barres, R., Eynon, N., & Voisin, S. (190703). Epigenetic changes in healthy human skeletal muscle following exercise- a systematic review. Epigenetics, 14(7), (633-648).

doi: 10.1080/15592294.2019.1614416

2019 Hiam, D., Voisin, S., Yan, X., Landen, S., Jacques, M., Papadimitriou, I. D., Munson, F., Byrnes, E., Brennan-Speranza, T. C., & Levinger, I. (190601). The association between bone mineral density gene variants and osteocalcin at baseline, and in response to exercise: The Gene SMART study. Bone, 123 (23-27).

doi: 10.1016/j.bone.2019.03.015

2019 Hiam, D., Patten, R., Gibson-Helm, M., Moreno-Asso, A., McIlvenna, L., Levinger, I., Harrison, C., Moran, L. J., Joham, A., & Parker, A. (190416). The effectiveness of high intensity intermittent training on metabolic, reproductive and mental health in women with polycystic ovary syndrome: Study protocol for the iHIT- randomised controlled trial. Trials, 20(1),

doi: 10.1186/s13063-019-3313-8

2019 Del, Coso., Hiam, D., Houweling, P., Perez, L. M., Eynon, N., & Lucia, A. (190130). More than a speed gene : ACTN3 R577X genotype, trainability, muscle damage, and the risk for injuries. European Journal of Applied Physiology, 119(1), (49-60).

doi: 10.1007/s00421-018-4010-0

2018 Trewin, A. J., Parker, L., Shaw, C. S., Hiam, D. S., Garnham, A., Levinger, I., McConell, G. K., & Stepto, N. K. (181127). Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 315(5), (R1003-R1016).

doi: 10.1152/ajpregu.00096.2018

2018 Bescos, R., Boden, M. J., Jackson, M. L., Trewin, A. J., Marin, E. C., Levinger, I., Garnham, A., Hiam, D. S., Falcao-Tebas, F., & Conte, F. (180601). Four days of simulated shift work reduces insulin sensitivity in humans. Acta Physiologica, 223(2),

doi: 10.1111/apha.13039

Research funding for the past 5 years

Please note:

  • Funding is ordered by the year the project commenced and may continue over several years.
  • Funding amounts for contact research are not disclosed to maintain commercial confidentiality.
  • The order of investigators is not indicative of the role they played in the research project.

Gene-specific methylation and its role in Polycystic Ovary Syndrome.
From: NHMRC - Centre for Research Excellence Award
For period: 2016-2017

Polycystic Ovary Syndrome: An Epigenetic Approach
From: NHMRC - Centre for Research Excellence Award
For period: 2015-2017

Supervision of research students at VU

Available to supervise research students

Not available for media queries

Currently supervised research students at VU

No. of students Study level Role
1 PhD Associate supervisor

Currently supervised research students at VU

Students & level Role
PhD (1) Associate supervisor

Professional memberships

  • Council member, Australian Physiological Society