Drug Design

Unit code: NPU3102 | Study level: Undergraduate
Credit points
12
(Generally, 1 credit = 10 hours of classes and independent study.)
Location
Footscray Park
Prerequisites
NPU2103 - Organic Synthesis
NPU2104 - Drug Discovery and Development
(Or equivalent to be determined by unit coordinator)
Overview
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Overview

This unit follows on from NPU2104 Drug Discovery and Development and examines the modern approaches used to discover and design drug and to bring pharmaceutical products to market. Students will undertake studies in rational structure-based drug design (SBDD) utilizing computational chemistry techniques.

Learning Outcomes

On successful completion of this unit, students will be able to:

  1. Review pharmaceutical methodology for the design of new drugs;
  2. Devise appropriate methodology for the design of new drugs;
  3. Using a representative computational chemistry software package, construct/ model potential drug molecules in terms of their structures and properties; and
  4. Conceptualize how pharmaceutical products are brought to market.

Assessment

For Melbourne campuses

Assessment type: Assignment
|
Grade: 10%
Selection of topic for investigation and outline of plan for article
Assessment type: Assignment
|
Grade: 20%
Article on topic of choice (1000 words)
Assessment type: Project
|
Grade: 40%
Computer-aided drug modelling including i) progress and ii) final assessment
Assessment type: Test
|
Grade: 30%
Short answer test based on class material and modelling experience (120mins)

Required reading

A copy of the Spartan Tutorial and User Guide will be loaned to each student for the period of the block.

RECOMMENDED TEXTS: Kristian Stromgaard, K., Krogsgaard-Larsen, P., Madsen, U., (2017) Textbook of Drug Design and Discovery 5th ed . CRC Press Patrick, G.L., 2006, An Introduction to Medicinal Chemistry, 3rd edn, Pear Education Ltd.

As part of a course

This unit is not compulsory for any specific course. Depending on the course you study, this unit may be taken as an elective.

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