| Year | Citation |
|---|---|
| 2018 | Kuang, J., Yan, X., Genders, A. J., Granata, C., & Bishop, D. J. (180501). An overview of technical considerations when using quantitative real-time PCR analysis of gene expression in human exercise research. PLoS ONE, 13(5), |
| 2018 | Yan, X., Dvir, N., Jacques, M., Cavalcante, L., Papadimitriou, I. D., Munson, F., Kuang, J., Garnham, A., Landen, S., & Li, J. (180101). ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the Gene SMART study. Journal of Applied Physiology, 125(3), (923-930). |
| 2017 | Yan, X., Eynon, N., Papadimitriou, I. D., Kuang, J., Munson, F., Tirosh, O., O'Keefe, L., Griffiths, L. R., Ashton, K. J., & Byrne, N. (171114). The gene SMART study: Method, study design, and preliminary findings. BMC Genomics, 18 |
| 2017 | Yang, R., Shen, X., Wang, Y., Voisin, S., Cai, G., Fu, Y., Xu, W., Eynon, N., Bishop, D. J., & Yan, X. (170401). ACTN3 R577X Gene Variant Is Associated with Muscle-Related Phenotypes in Elite Chinese Sprint/Power Athletes. Journal of Strength and Conditioning Research, 31(4), (1107-1115). |
| 2015 | Zhang, H., Guan, M., Townsend, K. L., Huang, T. L., An, D., Yan, X., Xue, R., Schulz, T. J., Winnay, J., & Mori, M. (151001). MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1 signaling network. EMBO Reports, 16(10), (1378-1393). |
| 2015 |
Voisin, S., Eynon, N., Yan, X., & Bishop, D. J. (150101). Exercise training and DNA methylation in humans. Acta Physiologica, 213(1), (39-59). doi: 10.1111/apha.12414 |
| 2013 |
Yan, X., Huang, Y., Zhao, J. X., Rogers, C. J., Zhu, M. J., Ford, S. P., Nathanielsz, P. W., & Du, M. (130401). Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. International Journal of Obesity, 37(4), (568-575). doi: 10.1038/ijo.2012.69 |
| 2011 | Yan, X., Huang, Y., Zhao, J. X., Long, N. M., Uthlaut, A. B., Zhu, M. J., Ford, S. P., Nathanielsz, P. W., & Du, M. (110701). Maternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring. Biology of Reproduction, 85(1), (172-178). |
| 2011 |
Yan, X., Huang, Y., Wang, H., Du, M., Hess, B. W., Ford, S. P., Nathanielsz, P. W., & Zhu, M. J. (110701). Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep. Inflammatory Bowel Diseases, 17(7), (1513-1522). doi: 10.1002/ibd.21539 |
| 2010 |
Yan, X., Zhu, M. J., Xu, W., Tong, J. F., Ford, S. P., Nathanielsz, P. W., & Du, M. (100101). Up-regulation of toll-like receptor 4/nuclear factor-B signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. Endocrinology, 151(1), (380-387). doi: 10.1210/en.2009-0849 |
Key details
Areas of expertise
- Exercise and muscle physiology with focus on cell signalling
- Nutrition and Dietary therapy in chronic diseases prevention and treatment
- Muscle Biochemistry
- Genetics and adaptation to training in health and disease
Available to supervise research students
Available for media queries
About Xu (Sean) Yan
Dr Sean Yan is an expert in muscle physiology and biochemistry. His research mainly focuses on nutrition, exercise and other lifestyle interventions in health and disease, with the aim to improve exercise performance and health outcomes.
Sean completed a Bachelor degree in China before moving to the United States for his postgraduate studies.
In 2012, Dr Yan was awarded a prestigious fellowship from the American Diabetes Association, working as a research fellow with Associate Professor Laurie Goodyear at Joslin Diabetes Centre, Harvard Medical School.
In 2013, Dr Yan was awarded the Victoria University Postdoctoral Research Fellowship and relocated to Australia. Dr Yan accepted a Lecturer position from the College of Health and Biomedicine in 2017 and was promoted to Senior Lecturer in 2019.
Dr Yan has published 29 peer-reviewed scientific journal articles (with an H-index of 15), and one book chapter, since 2009. Dr Yan has been awarded more than $280,000 of internal and external research grant funding since joining Victoria University.
Dr Yan contributes to undergraduate teaching in Biomedical Science, and supervises honours, masters (minor thesis) and PhD students in his area of research expertise.
Qualifications
- PhD, University of Wyoming (USA)
- MS, University of Wyoming (USA)
- BS, Tongji University (China)
Key publications
Xu (Sean) has over 43 publications, with a selection listed here.
A more comprehensive list of Xu (Sean)'s publications is available in the VU Research Repository.
Journal article (showing 10 of 32)
Research funding for the past 5 years
Please note:
- Funding is ordered by the year the project commenced and may continue over several years.
- Funding amounts for contact research are not disclosed to maintain commercial confidentiality.
- The order of investigators is not indicative of the role they played in the research project.
2018
|
The Effects of Resistance Training on Hypoxia-Induced Skeletal Muscle Loss in Humans
From: Beijing Sport University
Investigators: Prof David Bishop
For period: 2018-2019
|
Not disclosed |
2017
|
Active AMP Endurance Exercise Trial
From: Gencor Pacific
Investigators: Prof Andrew Mcainch, Prof Nigel Stepto, Prof Michael Mathai
For period: 2017-2018
|
Not disclosed |
2015
|
The influence of a common genetic variant (ACTN3 R577X) on changes in bone remodelling markers and the control of blood glucose following exercise training
From: The Jack Brockhoff Foundation
Investigators: Aspr Nir Eynon, Aspr Itamar Levinger, Prof David Bishop
For period: 2015-2017
|
$47,182 |
Supervision of research students at VU
Available to supervise research students
Available for media queries
Currently supervised research students at VU
| No. of students | Study level | Role |
|---|---|---|
| 1 | PhD | Not Specified supervisor |
| 1 | PhD | Principal supervisor |
Currently supervised research students at VU
| Students & level | Role |
|---|---|
| PhD (1) | Not Specified supervisor |
| PhD (1) | Principal supervisor |
Completed supervision of research students at VU
| No. of students | Study level | Role |
|---|---|---|
| 1 | PhD | Associate supervisor |
Completed supervision of research students at VU
| Students & level | Role |
|---|---|
| PhD (1) | Associate supervisor |
Other supervision of research students
Sean has supervised 7 honours students, 3 as principal supervisor.
Teaching activities & experience
Current teaching & coordination
- HBM3202, Applied Biomedical Science (Undergraduate course, Lecturer & Tutor), VU
- RBM2101 Pathophysiology and Quality Use of Medicine 1 (Undergraduate course, Unit Convener), VU
- HBM2106, Human Genetics (Undergraduate course, Unit Convener, Lecturer), VU
Past teaching & unit coordination
2018
- HBM3203, Integrative Physiology (Undergraduate course, Lecturer), Victoria University (VU)
- HBM2105, Medical Microbiology (Undergraduate course, Lecturer), VU
- RBM2530,Pathophysiology 1 (Undergraduate course, Tutor & Demonstrator), VU
- RBM1202, Bioscience II (Undergraduate course, Unit Convener, Lecturer), VU
2017
- HBM3200,Bioinformatics Methods (Undergraduate course, Unit Convener, Lecturer & Tutor), VU
- RBM2202, Pathophysiology and Quality Use of Medicine 2 (Undergraduate course, Unit Convener), VU
- HBM1101, Gene & Evolutionary Biology (Undergraduate course, Lecturer & Tutor), VU
- RBM1518, Human Physiology (Undergraduate course, Lecturer & Demonstrator), VU
- HBM1001, Anatomy & Physiology (Undergraduate course, Lecturer, Tutor & Demonstrator), VU
- RBM1103, Bioscience I (Undergraduate course, Lecturer), VU
- RBM1100, Function Anatomy of the Trunk (Undergraduate course, Lecturer), VU
- SCL3001, Exercise, Health & Disease (Undergraduate course, Tutor & Assessor), VU
2014 – 2016
- SSC3002, Sport Coaching (Undergraduate course, Demonstrator), VU
- SCL1002, Exercise Physiology (Undergraduate course, Coordinator, Lecturer & Tutor), VU
- AHE3100, Advanced Exercise Physiology (Undergraduate course, Lecturer & Tutor), VU
2010 – 2011
- Muscle structure and function (Postgraduate course, Teaching Assistant), University of Wyoming
- Cell signaling (Postgraduate course, Teaching Assistant), University of Wyoming
- Animal physiology (Undergraduate course, Teaching Assistant), University of Wyoming
Key academic roles
| Dates | Role | Department / Organisation |
|---|---|---|
| Jan 2019 - Feb 2019 |
Senior Research Fellow
|
Institute for Health and Sport, Victoria University |
| Jan 2018 - Feb 2019 |
Project Director
|
Australia Institute for Musculoskeletal Science |
| Jan 2018 - Dec 2018 |
Research Fellow
|
Institute for Health and Sport, Victoria University |
| Mar 2017 - Dec 2017 |
Research Associate
|
Institute of Sport, Exercise and Active Living, Victoria University |
| Jun 2013 - Mar 2017 |
Research Fellow
|
Institute of Sport, Exercise and Active Living, Victoria University |
| Aug 2011 - Jun 2013 |
Research Fellow
|
Joslin Diabetes Center, Harvard Medical School |
| Dates | Role & Department/Organisation |
|---|---|
| Jan 2019 -
Feb 2019
|
Senior Research Fellow
Institute for Health and Sport, Victoria University |
| Jan 2018 -
Feb 2019
|
Project Director
Australia Institute for Musculoskeletal Science |
| Jan 2018 -
Dec 2018
|
Research Fellow
Institute for Health and Sport, Victoria University |
| Mar 2017 -
Dec 2017
|
Research Associate
Institute of Sport, Exercise and Active Living, Victoria University |
| Jun 2013 -
Mar 2017
|
Research Fellow
Institute of Sport, Exercise and Active Living, Victoria University |
| Aug 2011 -
Jun 2013
|
Research Fellow
Joslin Diabetes Center, Harvard Medical School |
Awards
| Year | Award |
|---|---|
| 2019 |
DAAD RISE worldwide research scholarship - German Academic Exchange Service |
| 2018 |
DAAD RISE worldwide research scholarship - German Academic Exchange Service |
| 2017 |
DAAD RISE worldwide research scholarship - German Academic Exchange Service |
| 2016 |
Travel Award - CASS Foundation |
| 2016 |
DAAD RISE worldwide research scholarship - German Academic Exchange Service |
| 2015 |
Excellence in Research (Early Career) - College of Sport and Exercise Science, Victoria University. |
| 2013 |
Honorary Research Fellow - Murdoch Childrens Research Institute |
| 2013 |
Postdoctoral Research Fellowship - Victoria University |
| 2012 |
Postdoctoral Research Fellowship - American Diabetes Association |
| 2010 |
Brand of excellence scholarship - University of Wyoming |
Invited keynote speeches
| Year | Title/Description |
|---|---|
| 2017 |
The road to personalized exercise: lessons learned from the Gene SMART study The 3rd International Conference on Assistive Devices for Sports and Health Promotion (China) |
| 2016 |
The Gene SMART study, study design and preliminary data Washington State University (USA) |
| 2016 |
Personalised exercise training: the aspect of genetics Sport Science Forum, Beijing Sport University (China) |
| 2015 |
Genetic testing for athletic performance and trainability: Too early to be trusted. The University of Sao Paulo (Brazil) |
| 2014 |
From maternal obesity to offspring obesity, possible epigenetic mechanisms. 26th Congress of the Polish Physiological Society (Poland) |
Professional memberships
- Academic Member, Australian Diabetes Society
- Academic Member, American College of Sports Medicine
- Academic Member, Australian Physiological Society
- Academic Member, American Physiological Society
Media appearances
20th November 2014
Key member of the speed gene study team which was reported by ABC Catalyst
