Section: Overview
Overview
Key publications
Research funding
Supervising & teaching
Career

Key details

Areas of expertise

  • Exercise and muscle physiology with focus on cell signalling
  • Nutrition and Dietary therapy in chronic diseases prevention and treatment
  • Muscle Biochemistry
  • Genetics and adaptation to training in health and disease

Available to supervise research students

Available for media queries

About Xu (Sean) Yan

Dr Sean Yan is an expert in muscle physiology and biochemistry. His research mainly focuses on nutrition, exercise and other lifestyle interventions in health and disease, with the aim to improve exercise performance and health outcomes.

Sean completed a Bachelor degree in China before moving to the United States for his postgraduate studies.

In 2012, Dr Yan was awarded a prestigious fellowship from the American Diabetes Association, working as a research fellow with Associate Professor Laurie Goodyear at Joslin Diabetes Centre, Harvard Medical School.

In 2013, Dr Yan was awarded the Victoria University Postdoctoral Research Fellowship and relocated to Australia. Dr Yan accepted a Lecturer position from the College of Health and Biomedicine in 2017 and was promoted to Senior Lecturer in 2019.

Dr Yan has published 29 peer-reviewed scientific journal articles (with an H-index of 15), and one book chapter, since 2009. Dr Yan has been awarded more than $280,000 of internal and external research grant funding since joining Victoria University.

Dr Yan contributes to undergraduate teaching in Biomedical Science, and supervises honours, masters (minor thesis) and PhD students in his area of research expertise.

Qualifications

  • PhD, University of Wyoming (USA)
  • MS, University of Wyoming (USA)
  • BS, Tongji University (China)

Key publications

Year Citation
2018 Kuang, J., Yan, X., Genders, A. J., Granata, C., & Bishop, D. J. (180501). An overview of technical considerations when using quantitative real-time PCR analysis of gene expression in human exercise research. PLoS ONE, 13(5),

doi: 10.1371/journal.pone.0196438

2018 Yan, X., Dvir, N., Jacques, M., Cavalcante, L., Papadimitriou, I. D., Munson, F., Kuang, J., Garnham, A., Landen, S., & Li, J. (180101). ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the Gene SMART study. Journal of Applied Physiology, 125(3), (923-930).

doi: 10.1152/japplphysiol.00344.2018

2017 Yan, X., Eynon, N., Papadimitriou, I. D., Kuang, J., Munson, F., Tirosh, O., O'Keefe, L., Griffiths, L. R., Ashton, K. J., & Byrne, N. (171114). The gene SMART study: Method, study design, and preliminary findings. BMC Genomics, 18

doi: 10.1186/s12864-017-4186-4

2017 Yang, R., Shen, X., Wang, Y., Voisin, S., Cai, G., Fu, Y., Xu, W., Eynon, N., Bishop, D. J., & Yan, X. (170401). ACTN3 R577X Gene Variant Is Associated with Muscle-Related Phenotypes in Elite Chinese Sprint/Power Athletes. Journal of Strength and Conditioning Research, 31(4), (1107-1115).

doi: 10.1519/JSC.0000000000001558

2015 Zhang, H., Guan, M., Townsend, K. L., Huang, T. L., An, D., Yan, X., Xue, R., Schulz, T. J., Winnay, J., & Mori, M. (151001). MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1 signaling network. EMBO Reports, 16(10), (1378-1393).

doi: 10.15252/embr.201540837

2015 Voisin, S., Eynon, N., Yan, X., & Bishop, D. J. (150101). Exercise training and DNA methylation in humans. Acta Physiologica, 213(1), (39-59).

doi: 10.1111/apha.12414

2013 Yan, X., Huang, Y., Zhao, J. X., Rogers, C. J., Zhu, M. J., Ford, S. P., Nathanielsz, P. W., & Du, M. (130401). Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. International Journal of Obesity, 37(4), (568-575).

doi: 10.1038/ijo.2012.69

2011 Yan, X., Huang, Y., Zhao, J. X., Long, N. M., Uthlaut, A. B., Zhu, M. J., Ford, S. P., Nathanielsz, P. W., & Du, M. (110701). Maternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring. Biology of Reproduction, 85(1), (172-178).

doi: 10.1095/biolreprod.110.089649

2011 Yan, X., Huang, Y., Wang, H., Du, M., Hess, B. W., Ford, S. P., Nathanielsz, P. W., & Zhu, M. J. (110701). Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep. Inflammatory Bowel Diseases, 17(7), (1513-1522).

doi: 10.1002/ibd.21539

2010 Yan, X., Zhu, M. J., Xu, W., Tong, J. F., Ford, S. P., Nathanielsz, P. W., & Du, M. (100101). Up-regulation of toll-like receptor 4/nuclear factor-B signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. Endocrinology, 151(1), (380-387).

doi: 10.1210/en.2009-0849

Research funding for the past 5 years

Please note:

  • Funding is ordered by the year the project commenced and may continue over several years.
  • Funding amounts for contact research are not disclosed to maintain commercial confidentiality.
  • The order of investigators is not indicative of the role they played in the research project.

The Effects of Resistance Training on Hypoxia-Induced Skeletal Muscle Loss in Humans
From: Beijing Sport University
Investigators: Prof David Bishop
For period: 2018-2019
Not disclosed

Active AMP Endurance Exercise Trial
From: Gencor Pacific
Investigators: Prof Andrew Mcainch, Prof Nigel Stepto, Prof Michael Mathai
For period: 2017-2018
Not disclosed

The influence of a common genetic variant (ACTN3 R577X) on changes in bone remodelling markers and the control of blood glucose following exercise training
From: The Jack Brockhoff Foundation
Investigators: Aspr Nir Eynon, Aspr Itamar Levinger, Prof David Bishop
For period: 2015-2017
$47,182

Supervision of research students at VU

Available to supervise research students

Available for media queries

Currently supervised research students at VU

No. of students Study level Role
1 PhD Not Specified supervisor
1 PhD Principal supervisor

Currently supervised research students at VU

Students & level Role
PhD (1) Not Specified supervisor
PhD (1) Principal supervisor

Completed supervision of research students at VU

No. of students Study level Role
1 PhD Associate supervisor

Completed supervision of research students at VU

Students & level Role
PhD (1) Associate supervisor

Other supervision of research students

Sean has supervised 7 honours students, 3 as principal supervisor.

Teaching activities & experience

Current teaching & coordination

Past teaching & unit coordination

2018

  • HBM3203, Integrative Physiology (Undergraduate course, Lecturer), Victoria University (VU)
  • HBM2105, Medical Microbiology (Undergraduate course, Lecturer), VU
  • RBM2530,Pathophysiology 1 (Undergraduate course, Tutor & Demonstrator), VU
  • RBM1202, Bioscience II (Undergraduate course, Unit Convener, Lecturer), VU

2017

  • HBM3200,Bioinformatics Methods (Undergraduate course, Unit Convener, Lecturer & Tutor), VU
  • RBM2202, Pathophysiology and Quality Use of Medicine 2 (Undergraduate course, Unit Convener), VU
  • HBM1101, Gene & Evolutionary Biology (Undergraduate course, Lecturer & Tutor), VU
  • RBM1518, Human Physiology (Undergraduate course, Lecturer & Demonstrator), VU
  • HBM1001, Anatomy & Physiology (Undergraduate course, Lecturer, Tutor & Demonstrator), VU
  • RBM1103, Bioscience I (Undergraduate course, Lecturer), VU
  • RBM1100, Function Anatomy of the Trunk (Undergraduate course, Lecturer), VU
  • SCL3001, Exercise, Health & Disease (Undergraduate course, Tutor & Assessor), VU

2014 – 2016

  • SSC3002, Sport Coaching (Undergraduate course, Demonstrator), VU
  • SCL1002, Exercise Physiology (Undergraduate course, Coordinator, Lecturer & Tutor), VU
  • AHE3100, Advanced Exercise Physiology (Undergraduate course, Lecturer & Tutor), VU

2010 – 2011

  • Muscle structure and function (Postgraduate course, Teaching Assistant), University of Wyoming
  • Cell signaling (Postgraduate course, Teaching Assistant), University of Wyoming
  • Animal physiology (Undergraduate course, Teaching Assistant), University of Wyoming

Key academic roles

Dates Role Department / Organisation
Jan 2019 - Feb 2019
Senior Research Fellow
Institute for Health and Sport, Victoria University
Jan 2018 - Feb 2019
Project Director
Australia Institute for Musculoskeletal Science
Jan 2018 - Dec 2018
Research Fellow
Institute for Health and Sport, Victoria University
Mar 2017 - Dec 2017
Research Associate
Institute of Sport, Exercise and Active Living, Victoria University
Jun 2013 - Mar 2017
Research Fellow
Institute of Sport, Exercise and Active Living, Victoria University
Aug 2011 - Jun 2013
Research Fellow
Joslin Diabetes Center, Harvard Medical School
Show more academic roles
Dates Role & Department/Organisation
Jan 2019 -
Feb 2019
Senior Research Fellow
Institute for Health and Sport, Victoria University
Jan 2018 -
Feb 2019
Project Director
Australia Institute for Musculoskeletal Science
Jan 2018 -
Dec 2018
Research Fellow
Institute for Health and Sport, Victoria University
Mar 2017 -
Dec 2017
Research Associate
Institute of Sport, Exercise and Active Living, Victoria University
Jun 2013 -
Mar 2017
Research Fellow
Institute of Sport, Exercise and Active Living, Victoria University
Aug 2011 -
Jun 2013
Research Fellow
Joslin Diabetes Center, Harvard Medical School
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Awards

Year Award
2019

DAAD RISE worldwide research scholarship - German Academic Exchange Service

2018

DAAD RISE worldwide research scholarship - German Academic Exchange Service

2017

DAAD RISE worldwide research scholarship - German Academic Exchange Service

2016

Travel Award - CASS Foundation

2016

DAAD RISE worldwide research scholarship - German Academic Exchange Service

2015

Excellence in Research (Early Career) - College of Sport and Exercise Science, Victoria University.

2013

Honorary Research Fellow - Murdoch Childrens Research Institute

2013

Postdoctoral Research Fellowship - Victoria University

2012

Postdoctoral Research Fellowship - American Diabetes Association

2010

Brand of excellence scholarship - University of Wyoming

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Invited keynote speeches

Year Title/Description
2017

The road to personalized exercise: lessons learned from the Gene SMART study

The 3rd International Conference on Assistive Devices for Sports and Health Promotion (China)

2016

The Gene SMART study, study design and preliminary data

Washington State University (USA)

2016

Personalised exercise training: the aspect of genetics

Sport Science Forum, Beijing Sport University (China)

2015

Genetic testing for athletic performance and trainability: Too early to be trusted.

The University of Sao Paulo (Brazil)

2014

From maternal obesity to offspring obesity, possible epigenetic mechanisms.

26th Congress of the Polish Physiological Society (Poland)

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Professional memberships

  • Academic Member, Australian Diabetes Society
  • Academic Member, American College of Sports Medicine
  • Academic Member, Australian Physiological Society
  • Academic Member, American Physiological Society

Media appearances

20th November 2014

Genetic ID on training

Key member of the speed gene study team which was reported by ABC Catalyst