Section: Overview
Overview
Key publications
Research funding
Supervising & teaching
Career

Key details

Areas of expertise

  • Cancer
  • Identification of molecular mediators of cancer metastasis
  • Stress biology
  • Pre-clinical Testing of Anti-Cancer Drugs
  • Cancer Treatment Resistance

Available to supervise research students

Not available for media queries

About John Price

Professor John T. Price is a cancer cell and molecular biologist with an internationally renowned research track record in the study of the cellular and molecular biology of cancer metastasis.

His research focuses upon:

  • identification and therapeutic targeting of molecular mediators of cancer metastasis
  • the role which stress transcriptional networks play in cancer progression
  • development of novel therapeutics towards molecular mediators of metastasis
  • elucidating the impact of anticancer therapies upon metastasis and bone integrity.

His lab uses a variety of cellular, molecular, pharmacological and in vivo experimental approaches to address these major research questions.

John holds a number of other academic research positions including being a Program Director at the Australian Institute for Musculoskeletal Science and holding adjunct positions at the University of Melbourne and Monash University. He is also currently is a member of the International Board of Directors for the Metastasis Research Society and is a past Vice-President of the Australian Metastasis Research Society (OzMRS).

His work has been recognised by a number of fellowships and awards including a NHMRC RD Wright Fellowship, Bristol-Myers Squib Oncology AACR Young Investigator Award and the International Journal of Oncology and Molecular Medicine Outstanding Achievement award for his work elucidating the negative effects of HSP90 inhibitors in cancer metastasis to the bone.

Qualifications

  • BSc (Hons), University of Aberdeen, Scotland, 1992
  • PhD, University of Aberdeen, Scotland, 1996

Key publications

Year Citation
2011 Kouspou, M. M., & Price, J. T. (111024). Analysis of cellular migration using a two-chamber methodology (pp. 303-317).

doi: 10.1007/978-1-61779-295-3_23

Year Citation
2017 Chai, R. C., Vieusseux, J. L., Lang, B. J., Nguyen, C. H., Kouspou, M. M., Britt, K. L., & Price, J. T. (170501). Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors. Molecular oncology, 11(5), (567-583).

doi: 10.1002/1878-0261.12054

2015 Ooms, L. M., Binge, L. C., Davies, E. M., Rahman, P., Conway, J. RW., Gurung, R., Ferguson, D. T., Papa, A., Fedele, C. G., & Vieusseux, J. L. (150810). The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Cancer Cell, 28(2), (155-169).

doi: 10.1016/j.ccell.2015.07.003

2014 Teoh, S. SY., Vieusseux, J., Prakash, M., Berkowicz, S., Luu, J., Bird, C. H., Law, R. HP., Rosado, C., Price, J. T., & Whisstock, J. C. (140120). Maspin is not required for embryonic development or tumour suppression. Nature Communications, 5

doi: 10.1038/ncomms4164

2014 Chai, R. C., Kouspou, M. M., Lang, B. J., Nguyen, C. H., Van, Der., Vieusseux, J. L., Lim, R. C., Gillespie, M. T., Benjamin, I. J., & Quinn, J. MW. (140101). Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner. Journal of Biological Chemistry, 289(19), (13602-13614).

doi: 10.1074/jbc.M113.530626

2013 Nguyen, C. H., Lang, B. J., Chai, R. CC., Vieusseux, J. L., Kouspou, M. M., & Price, J. T. (130601). Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status. Biochemical Journal, 452(2), (321-329).

doi: 10.1042/BJ20130098

2013 Van, Der., Chai, R. CC., Singh, P. P., Lang, B. J., Xu, J., Gillespie, M. T., Price, J. T., & Quinn, J. MW. (130415). HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors. Biochemical Journal, 451(2), (235-244).

doi: 10.1042/BJ20121626

2010 Fedele, C. G., Ooms, L. M., Ho, M., Vieusseux, J., O'Toole, S. A., Millar, E. K., Lopez-Knowles, E., Sriratana, A., Gurung, R., & Baglietto, L. (101221). Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proceedings of the National Academy of Sciences of the United States of America, 107(51), (22231-22236).

doi: 10.1073/pnas.1015245107

2005 Price, J. T., Quinn, J. MW., Sims, N. A., Vieusseux, J., Waldeck, K., Docherty, S. E., Myers, D., Nakamura, A., Waltham, M. C., & Gillespie, M. T. (050601). The heat shock protein 90 inhibitor, 17-allylamino-17- demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line. Cancer Research, 65(11), (4929-4938).

doi: 10.1158/0008-5472.CAN-04-4458

2004 Pereira, J. J., Meyer, T., Docherty, S. E., Reid, H. H., Marshall, J., Thompson, E. W., Rossjohn, J., & Price, J. T. (040201). Bimolecular Interaction of Insulin-Like Growth Factor (IGF) Binding Protein-2 with v3 Negatively Modulates IGF-I-Mediated Migration and Tumor Growth. Cancer Research, 64(3), (977-984).

doi: 10.1158/0008-5472.CAN-03-3056

Research funding for the past 5 years

Please note:

  • Funding is ordered by the year the project commenced and may continue over several years.
  • Funding amounts for contact research are not disclosed to maintain commercial confidentiality.
  • The order of investigators is not indicative of the role they played in the research project.

Stop the Mets.
From: The University of Melbourne, VU Foundation
For period: 2017-2017
$31,400

Unimutual Insurance Claim for Price Lab - College of Health and Biomedicine.
From: UniMutual Ltd
Investigators: Ms Madonna Hannan
For period: 2016-2017
Not disclosed

Impact of Molecular Stress upon Osteoblast Lineage Cell Function; Identification of HSF1 as a Novel Therapeutic Target in Pathological; Bone Loss
From: Australian Institute for Musculoskeletal Science (AIMSS)
For period: 2015-2015
$9,091

Supervision of research students at VU

Available to supervise research students

Not available for media queries

Currently supervised research students at VU

No. of students Study level Role
2 Masters by Research Principal supervisor
4 PhD Principal supervisor
1 PhD Withdrawn supervisor

Currently supervised research students at VU

Students & level Role
Masters by Research (2) Principal supervisor
PhD (4) Principal supervisor
PhD (1) Withdrawn supervisor

Completed supervision of research students at VU

No. of students Study level Role
1 PhD Associate supervisor

Completed supervision of research students at VU

Students & level Role
PhD (1) Associate supervisor

Careers

Details of this Researcher's career are currently unavailable.