Section: Overview
Overview
Key publications
Research funding
Supervising & teaching
Career

Key details

Areas of expertise

  • Cardiovascular and kidney diseases
  • Nutrition and dietary therapy in chronic diseases prevention and treatment
  • Examining the role of the Mas receptor in endothelial dysfunction
  • Cancer

Available to supervise research students

Available for media queries

About Anthony Zulli

Dr Zulli joined Victoria University after finishing his NHMRC Peter Doherty Fellowship in 2009 (2006-2009, University of Melbourne, Austin Health). Dr Zulli's research focuses on the mechanisms that cardiovascular disease risk factors (homocysteine/cholesterol) cause endothelial dysfunction. His research has an emphasis on the nitric oxide pathway, oxidative stress and the renin-angiotensin system, and has a recent interest on reducing kidney disease caused by cancer treatments. Dr Zulli has been funded by the National Heart Foundation and NHMRC, as well as internal VU grant schemes. His pharmacology laboratory is equipped with 80 organ bath units, were he studies blood vessels from the microvasculature (60 micron diameter) to large conduit arteries (2-4mm diameter). His approved research utilises rabbits, rats, guinea pigs and mice.

His work has recently shown that the cardiovascular risk factor homocysteine could affect the efficacy of antioxidant therapy, and his collaborative work has shown that hormones released from bone can 'talk' to blood vessels during stress, improving their function.

He has published over 80 manuscripts, attracted over $1 million in funds and collaborates with local, national and international scientists.

Qualifications

  • PhD, University of Melbourne, 2009
  • GCTE, Victoria University

Key publications

Year Citation
2022 Ranasinghe, R., Mathai, M. L., & Zulli, A. (220901). Cisplatin for cancer therapy and overcoming chemoresistance. Heliyon, 8(9),

doi: 10.1016/j.heliyon.2022.e10608

2022 Gunarathne, L. S., Rajapaksha, I. G., Casey, S., Qaradakhi, T., Zulli, A., Rajapaksha, H., Trebicka, J., Angus, P. W., & Herath, C. B. (220901). Mas-related G protein-coupled receptor type D antagonism improves portal hypertension in cirrhotic rats. Hepatology Communications, 6(9), (2523-2537).

doi: 10.1002/hep4.1987

2022 Ranasinghe, R., Mathai, M., & Zulli, A. (220701). Revisiting the therapeutic potential of tocotrienol. BioFactors, 48(4), (813-856).

doi: 10.1002/biof.1873

2022 Matsoukas, J. M., Gadanec, L. K., Zulli, A., Apostolopoulos, V., Kelaidonis, K., Ligielli, I., Moschovou, K., Georgiou, N., Plotas, P., & Chasapis, C. T. (220701). Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2. Biomedicines, 10(7),

doi: 10.3390/biomedicines10071731

2022 Ridgway, H., Chasapis, C. T., Kelaidonis, K., Ligielli, I., Moore, G. J., Gadanec, L. K., Zulli, A., Apostolopoulos, V., Mavromoustakos, T., & Matsoukas, J. M. (220501). Understanding the Driving Forces That Trigger Mutations in SARSCoV2: Mutational Energetics and the Role of Arginine Blockers in COVID19 Therapy. Viruses, 14(5),

doi: 10.3390/v14051029

2022 Ranasinghe, R., Mathai, M., & Zulli, A. (220301). A synopsis of modern - day colorectal cancer: Where we stand. Biochimica et Biophysica Acta - Reviews on Cancer, 1877(2),

doi: 10.1016/j.bbcan.2022.188699

2022 Ridgway, H., Moore, G. J., Mavromoustakos, T., Tsiodras, S., Ligielli, I., Kelaidonis, K., Chasapis, C. T., Gadanec, L. K., Zulli, A., & Apostolopoulos, V. (220101). Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2. Computational and Structural Biotechnology Journal, 20 (2091-2111).

doi: 10.1016/j.csbj.2022.04.010

2021 Tacey, A., Hayes, A., Zulli, A., & Levinger, I. (210701). Osteocalcin and vascular function: is there a cross-talk?. Molecular Metabolism, 49

doi: 10.1016/j.molmet.2021.101205

2021 Moore, G. J., Pires, J. M., Kelaidonis, K., Gadanec, L. K., Zulli, A., Apostolopoulos, V., & Matsoukas, J. M. (210701). Receptor interactions of angiotensin ii and angiotensin receptor blockersrelevance to covid-19. Biomolecules, 11(7),

doi: 10.3390/biom11070979

2021 Liskova, A., Samec, M., Koklesova, L., Brockmueller, A., Zhai, K., Abdellatif, B., Siddiqui, M., Biringer, K., Kudela, E., & Pec, M. (210601). Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles. EPMA Journal, 12(2), (155-176).

doi: 10.1007/s13167-021-00242-5

Research funding for the past 5 years

Please note:

  • Funding is ordered by the year the project commenced and may continue over several years.
  • Funding amounts for contact research are not disclosed to maintain commercial confidentiality.
  • The order of investigators is not indicative of the role they played in the research project.

The role of osteocalcin in blood vessel disease: A novel approach to fight blood vessels disease.
From: Rebecca L Cooper Medical Research Foundation Limited
Other investigators: Prof Itamar Levinger
For period: 2017-2018
$24,900

Supervision of research students at VU

Available to supervise research students

Available for media queries

Currently supervised research students at VU

No. of students Study level Role
2 PhD Principal supervisor
1 PhD Associate supervisor

Currently supervised research students at VU

Students & level Role
PhD (2) Principal supervisor
PhD (1) Associate supervisor

Completed supervision of research students at VU

No. of students Study level Role
2 PhD Associate supervisor
1 PhD Principal supervisor
1 Masters by Research Associate supervisor

Completed supervision of research students at VU

Students & level Role
PhD (2) Associate supervisor
PhD (1) Principal supervisor
Masters by Research (1) Associate supervisor

Teaching activities & experience

Unit Coordinator for RBM3800: Pharmacology

Keynote and invited speeches

Year Title/Description
2019

Lifestyle and coronary artery disease

Ausmed Education: The Nurse Health Coach Conference (28-29 October)

2019

Coronary artery disease and homocysteine

Ausmed Education: Chronic Disease Conference (9-10 September)

Professional memberships

  • Secretary, Australian Vascular Biology Society
  • Academic Member, Australian Atherosclerosis Society

Media appearances

28th June 2017

Chilli peppers and weight loss

ABC Melbourne Breakfast Show