Dr Melanie Sullivan-Gunn is a Lecturer in the College of Health and Biomedicine with a research interest in the pathophysiology of skeletal and cardiac muscle atrophy.
Dr Sullivan-Gunn's research focuses particularly on skeletal and cardiac muscle oxidative stress and proteolysis pathways in cancer cachexia and aging sarcopenia. She has extensive experience in the development and handling of the Murine Adenocarcinoma (MAC16) mouse model of cancer induced cachexia and is also involved in projects investigating novel treatments to improve muscle wasting in the cancer cachectic heart and skeletal muscle.
Refereed Journal Articles
Vaughan, VC, Sullivan-Gunn, M, Hinch, E, Martin, P & Lewandowski, PA (2012) 'Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia', PLoS One, vol. 7, no. 9, p. e45900.
Janevski, M, Antonas, KN, Sullivan-Gunn, MJ, McGlynn, MA & Lewandowski, PA (2011) 'The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH', Comp Hepatol, vol. 10, no. 1, p. 10.
Sullivan-Gunn, M, Hinch, E, Vaughan, V & Lewandowski, P (2011) 'Choosing a stable housekeeping gene and protein is essential in generating valid gene and protein expression results', Br J Cancer, vol. 104, no. 6, p. 1055; author reply 6.
Sullivan-Gunn, MJ, Campbell-O'Sullivan, SP, Tisdale, MJ & Lewandowski, PA (2011) 'Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle', J Cachexia Sarcopenia Muscle, vol. 2, no. 3, pp. 181-8.
Areas of expertise
- Muscle oxidative stress and proteolysis
- Muscle wasting in cancer induced cachexia and aging sarcopenia
- Skeletal and cardiac muscle metabolism, atrophy and hypertrophy