Dr Craig A. Goodman
Senior Lecturer, College of Health & Biomedicine
As an undergraduate, Craig majored in exercise physiology, biochemistry and anatomy at Victoria University. His passion for skeletal muscle function and adaptation led him to undertake his Honours and PhD Degrees in skeletal muscle physiology and biochemistry, focusing on glycogen metabolism, developmental age and myosin heavy chain composition on excitation-contraction coupling properties of single muscle fibers.
After his PhD studies, Craig gained a post-doc position examining the role of the Na+,K+-ATPase in skeletal muscle fatigue and then obtained the position of Lecturer in exercise physiology at Victoria University. In this position Craig’s research examined taurine supplementation on muscle performance, and acute and chronic resistance exercise on performance and health in humans.
In 2007, Craig took a research position at the University of Melbourne to examine the effect of statin medications on muscle atrophy and metabolism. Then, in 2009, Craig moved to the USA to undertake studies on the regulation of skeletal muscle mass and, in particular, the role of the enzyme mTOR in mechanical load-induced muscle hypertrophy at the University of Wisconsin-Madison.
Since returning to Australia in 2014, Craig has obtained the position of Senior Lecturer in the College of Health and Biomedicine, where he continues his interest in the molecular mechanisms that regulate skeletal muscle mass and function.
Refereed journal articles
Goodman CA, Hornberger TA and Robling AG (2015) Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms. Bone (in press)
Goodman CA, Pol D, Zacharewicz E, Lee-Young RS, Snow RJ, Russell AP, and McConell GK (2015) Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1a Protein and Mitochondrial Content. PLoS One 10(5): e0128398.
Goodman CA, Dietz JM, Jacobs BL, McNally RM, You JS and Hornberger TA (2015) Yes-associated protein is up regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy. FEBS 589(13): 1491-1497.
Goodman CA (2014) The role of mTORC1 in the regulation of protein synthesis and skeletal muscle mass in response to various mechanical stimuli. Reviews in Physiology, Biochemistry and Pharmacology. 166:43-95
Goodman CA, McNally RM, Hoffmann FM and Hornberger TA (2013) Smad3 Induces Atrogin-1, Inhibits mTOR and Protein Synthesis, and Promotes Muscle Atrophy In Vivo. Molecular Endocrinology. 27(11): 1946-1957.
View Craig's full publication list in the Victoria University Research Repository.
Postgraduate research students and fellows
- 2 Honour students (Supervisor)
- 2 Honours students (Co-Supervisor)
- 2 PhD students (Co-Supervisor)
- 5 Research Project Students (Supervisor)
Co-supervision of 3 Honours students
Goodman CA and Hornberger TA (2012-2014)R21 National Institutes of Health (NIH) Exploratory/Developmental Research Grant Award - The role of TCTP in the regulation of skeletal muscle mass. $406,350.
Australian Physiological Society (AuPS)
Areas of expertise
- Acute responses and chronic adaptations to resistance exercise
- Cell growth and cell signalling
- Structural, functional and biochemical differences between muscle fiber types
- The mechanical regulation of mTORC1 signalling and protein synthesis
- The regulation of skeletal muscle mass in health and disease