Epigenetics a potential cause of insulin resistance in Polycystic Ovary Syndrome

Epigenetics a potential cause of insulin resistance in Polycystic Ovary Syndrome

Researchers in our team are looking for 18 to 45 year old women to participate in 2 sessions that will help us better understand if women with Polycystic Ovary Syndrome (PCOS) have unique epigenetics signatures when compared to women without the syndrome.

About the study

Polycystic Ovary Syndrome (PCOS) is one of the most common female hormonal disorders resulting in reproductive, psychological and metabolic impacts.

Emerging evidence has highlighted the possible role of epigenetic* factors in the aetiology of PCOS.

*Epigenetic factors -  is how genes can be turned on or off in response to environmental factors such as diet and exercise.

The study aims to investigate whether women with PCOS have unique epigenetics signatures when compared to women without the syndrome.

Eligibility

To be eligible to participate you:

  • must be female aged between 18-45 years of age
  • can be with or without Polycystic Ovary Syndrome
  • must not be taking the contraceptive pill or insulin sensitisers (i.e Metformin).

Take note of the following exclusion criteria (meaning you cannot partipicate). You cannot participate if you are:

  • a woman with known cardiovascular disease
  • a woman with type 2 diabetes
  • pregnant 
  • a current smoker and other conditions (for more details please contact the research team).

Trial process

Trials will be conducted at Victoria University- Footscray Park campus.

It will involve 2 sessions. The first will take only half an hour and the second session takes approximately 3.5-4 hours of your time.

You be asked to undergo:

  • a series of blood sampling for an oral glucose tolerance test
  • body composition via DEXA body scan
  • physical activity and dietary monitoring.

Benefits of participating in this study

We cannot guarantee that you will gain any direct benefit from this study, but you may gain a better understanding of your general health. For women with PCOS you main gain a greater understanding of your condition.

As a token of our gratitude you will receive a $20 gift voucher immediately after completing the final trial session for contributing your time to the study.

Findings from the study will provide invaluable insight into the cause of PCOS, and the potential role of epigenetics in this complex syndrome which may lead to improved treatment in the future. 

Express interest in the study

If you are interesting in partipating in this epigenetic and PCOS research study contact: